Genetic variation explains residual CHD risk with statin therapy
نویسندگان
چکیده
منابع مشابه
Managing residual risk in patients receiving statin therapy. Comment.
Until the results of several statin trials are available, it is recommended that the current indications and usage of ezetimibe be continued.
متن کاملRisk for myopathy with statin therapy in high-risk patients.
Emerging data suggest that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) offer important benefits for the large population of individuals at high risk for coronary heart disease. This population encompasses a sizable portion of individuals who are also at high risk for drug-drug interactions due to their need for multiple medications. In general, statins are...
متن کاملPredictors of residual cardiovascular risk in patients on statin therapy for primary prevention.
BACKGROUND Low-density lipoprotein cholesterol-lowering therapy is an important aspect of primary prevention of cardiovascular disease (CVD). Statins are the most widely used drug therapy for achieving low-density lipoprotein goals based on an individual's 10-year risk. However, substantial risk of CVD events still exists even when a person is on statins. We sought to explore the predictors of ...
متن کاملAtherogenic dyslipidemia and residual cardiovascular risk in statin-treated patients.
BACKGROUND AND PURPOSE Treatment with statins reduces the rate of cardiovascular events in high-risk patients, but residual risk persists. At least part of that risk may be attributable to atherogenic dyslipidemia characterized by low high-density lipoprotein cholesterol (≤40 mg/dL) and high triglycerides (triglycerides≥150 mg/dL). METHODS We studied subjects with stroke or transient ischemic...
متن کاملIdentification of genetic variants associated with response to statin therapy.
OBJECTIVE The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins. METHODS AND RESULTS 49 tagging and candidate polymorphisms in 9 genes were genotyped in 1507 post-ACS subjects randomized to atorvastatin or pravastatin. Two polymorphisms (rs7412, rs42...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2018
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-018-0034-8